A scientist in a white lab coat and protective gloves is performing a biomolecular analysis using capillary electrophoresis equipment in a state-of-the-art laboratory.

Your molecule is very important to us and will be treated with the utmost confidentiality and care. Our team of capillary electrophoresis experts cover a diverse range of CE-based bioanalytical methods for a wide variety of molecules. Here are just a few examples:

What sample can we analyze for you today?

Reduced SDS-CAGE analysis of monoclonal antibody sample.

Both reduced and intact forms of the therapeutic were analyzed using a “hump-free” 0.8% agarose-TBE composition gel.

ZOOMED-IN SECTION OF BASELINE-SEPARATED PEAKS OF A REDUCED, ANTI-COVID-19 MONOCLONAL ANTIBODY SAMPLE ALONGSIDE THE CO-INJECTED INTACT FORM, WITH A STABLE, HUMP-FREE BASELINE.

Capillary isoelectric focusing (cIEF) analysis of
an anti-cancer monoclonal antibody therapeutic.

Section A: Basic peaks; Section B: Main peak;
Section C: Acidic peaks region 1; Section D: Acidic peaks region 2.

CAPILLARY ISOELECTRIC FOCUSING (CIEF) ANALYSIS OF A CYTOTOXIC MONOCLONAL ANTIBODY, IDENTIFYING ITS MAIN ISOFORM AS WELL AS BASIC AND ACIDIC CHARGE VARIANTS.

Filep C, Szigeti M, Farsang R, Haberger M, Reusch D, Guttman A. Multilevel capillary gel electrophoresis characterization of new antibody modalities. Anal Chim Acta. 2021 Jun 29;1166:338492. doi: 10.1016/j.aca.2021.338492.

N-glycan profiling and sequencing

N-glycan profiling (Panel A) and sequencing (Panel B) of an anti-Covid-19 monoclonal antibody drug via CGE-LIF.

Triplicate runs of N-glycan profiling for a Covid-19 monoclonal antibody sample, analyzed alongside a glycan ladder using Capillary Gel Electrophoresis with Laser-Induced Fluorescence (CGE-LIF).

A

N-glycan profiling (Panel A) and sequencing (Panel B) of an anti-Covid-19 monoclonal antibody drug via CGE-LIF.

Triplicate runs of N-glycan profiling for a Covid-19 monoclonal antibody sample, analyzed alongside a glycan ladder using Capillary Gel Electrophoresis with Laser-Induced Fluorescence (CGE-LIF). The right panel shows the sequencing traces after sialidase, galactosidase and hexoseaminidase digestions.

B

Szabo M, Sarkozy D, Szigeti M, Farsang R, Kardos Z, Kozma A, Csanky E, Chung DS, Szekanecz Z, Guttman A. Introduction of a Capillary Gel Electrophoresis-Based Workflow for Biotherapeutics Characterization: Size, Charge, and N-Glycosylation Variant Analysis of Bamlanivimab, an Anti-SARS-CoV-2 Product. Front Bioeng Biotechnol. 2022 Mar 8;10:839374. doi: 10.3389/fbioe.2022.839374.

Sample analysis Request

Simply fill out the form below and we will get back to you within 2 business days to discuss logistics including confidentiality, scope, and compensation. Please be sure to provide your business email address and a telephone number where you can be reached. Completing the address section will let us know what time zone you are in so we will be sure to contact you during your business hours only. We look much forward to partner with you.

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